diff a/src/jdk.internal.vm.compiler/share/classes/org.graalvm.compiler.hotspot.test/src/org/graalvm/compiler/hotspot/test/CheckGraalIntrinsics.java b/src/jdk.internal.vm.compiler/share/classes/org.graalvm.compiler.hotspot.test/src/org/graalvm/compiler/hotspot/test/CheckGraalIntrinsics.java
--- a/src/jdk.internal.vm.compiler/share/classes/org.graalvm.compiler.hotspot.test/src/org/graalvm/compiler/hotspot/test/CheckGraalIntrinsics.java
+++ b/src/jdk.internal.vm.compiler/share/classes/org.graalvm.compiler.hotspot.test/src/org/graalvm/compiler/hotspot/test/CheckGraalIntrinsics.java
@@ -421,10 +421,15 @@
                             "com/sun/crypto/provider/ElectronicCodeBook.implECBEncrypt([BII[BI)I",
                             "java/math/BigInteger.shiftLeftImplWorker([I[IIII)V",
                             "java/math/BigInteger.shiftRightImplWorker([I[IIII)V");
         }
 
+        if (isJDK16OrHigher()) {
+            add(toBeInvestigated,
+                            "sun/security/provider/MD5.implCompress0([BI)V");
+        }
+
         if (!config.inlineNotify()) {
             add(ignore, "java/lang/Object.notify()V");
         }
         if (!config.inlineNotifyAll()) {
             add(ignore, "java/lang/Object.notifyAll()V");
@@ -591,10 +596,18 @@
 
     private static boolean isJDK14OrHigher() {
         return JavaVersionUtil.JAVA_SPEC >= 14;
     }
 
+    private static boolean isJDK15OrHigher() {
+        return JavaVersionUtil.JAVA_SPEC >= 15;
+    }
+
+    private static boolean isJDK16OrHigher() {
+        return JavaVersionUtil.JAVA_SPEC >= 16;
+    }
+
     public interface Refiner {
         void refine(CheckGraalIntrinsics checker);
     }
 
     @Test